LKT Labs- AB-680#A040068解決方案
AB-680是CD73的抑制劑,CD 在腫瘤生長、轉移和腫瘤相關巨噬細胞上調中起關鍵作用。
Cas No.:2105904-82-1
純度:≥98%
公式:C20H24氯氟乙烯4O9P2
配方重量:580.83
IUPAC名稱:[[(2R,3S,4R,5R)-5-[6-氯-4-[[(1S)-1-(2-氟苯基)乙基]氨基]吡唑竝[3,4-b]吡啶-1-基]-3,4-二羥基氧代-2-基]甲氧基羥基磷酸基]甲基膦酸
同義詞:AB680, 奎姆利盧司他
外觀:類白色粉末
儲存溫度:-20°C
LKT Labs-AB-680文獻引用:
Faraoni E, Strickland L, O’Brien B, et al. Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma. Front Oncol. 2022 Sep 6;12:995027. PMID: 36147911
Noh J, Lee I, Han N, et al. Additive effect of CD73 inhibitor in colorectal cancer treatment with CDK4/6 inhibitor through regulation of PD-L1. Cell Mol Gastroenterol Hepatol. 2022;14(4):769-788. PMID: 35843546
Kim M, Min Y, Jang J, et al. Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer. J Immunother Cancer. 2021 Jul;9(7):e002503. PMID: 34253638
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